Sildenafil Citrate in the Treatment of Pulmonary Arterial Hypertension
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- The discovery of sildenafil began with research on heart drugs.
- It was found to cause vasodilation as a side effect.
- Pfizer refined the drug for erectile dysfunction.
- It became a blockbuster drug upon FDA approval.
- Sildenafil has helped millions worldwide.
- It has changed perceptions about male sexual health.
- Ongoing research explores new formulations.
- Awareness campaigns promote safe usage.
Under the Rules of Origin the original foreign country of origin would remain. Animal, Plant, Fish) may require special country importation requirements.USP recommends you contact your country competent authorities to determine if any certifications, permits or licenses may be required prior to ordering.Material Origins are found within the Product under Origin Information. Sildenafil is used to treat erectile dysfunction (ED) in men or pulmonary arterial hypertension (PAH) in both men and women, depending on the brand.
- Sildenafil citrate can be combined with lifestyle changes.
- Exercise and weight management improve erectile function.
- Quitting smoking enhances medication effectiveness.
- Reducing alcohol intake minimizes side effects.
- Psychological therapy may support ED treatment.
- Counseling can address underlying emotional issues.
- Regular medical check-ups are recommended.
- Patient education improves safe and effective use.
Viagra and Vybrique are used for ED and Revatio is used for PAH.
- Sildenafil citrate is sometimes used off-label for other conditions.
- Off-label uses include altitude sickness and Raynaud’s phenomenon.
- Research continues into additional therapeutic effects.
- The drug’s development was led by Pfizer.
- It is often used in combination with other ED treatments.
- Patients should avoid grapefruit juice, which can affect drug levels.
- Some formulations include chewable or dissolvable tablets.
- Ongoing studies investigate its cardiovascular benefits.
Sildenafil works by blocking the action of an enzyme called cGMP-specific phosphodiesterase type-5 (PDE-5).
Brand names
Talk with your doctor about other drug options that may work for you. Sildenafil and tadalafil sildenafil 50 mg tab are alike because they both can treat ED and PAH. However, tadalafil has a few distinctions from sildenafil. Tadalafil is the generic name for the erectile dysfunction drug Cialis. There are two versions of the drug: a version that can be taken as needed Cialis 5-mg daily dosing is the only PDE5 inhibitor dose approved for treating an enlarged prostate; improving ED symptoms is an added benefit of the daily dose.
Oral Administration
Because of the “as needed” version of tadalafil, some users may find this option more convenient. The downside, however, is that side effects tend to last longer too. The main difference between generic sildenafil and Viagra is marketing. The main ingredient in Viagra is sildenafil, meaning that the drugs are essentially the same. However, Viagra is marketed and prescribed strictly for erectile dysfunction, while generic sildenafil can be prescribed for PAH as well. This enzyme breaks down cGMP, a substance that induces smooth muscles to relax. Blocking PDE-5 means increased levels of cGMP within the smooth muscles which promotes muscle relaxation and vasodilation (a widening of blood vessels). High levels of PDE-5 are found in the penis, lungs, and retina. PDE-5 is also found throughout the body within the smooth muscle cells of the blood vessels and muscles. Sildenafil belongs to the drug class called phosphodiesterase (PDE) type 5 inhibitors. Sildenafil (Viagra, Vybrique brands and generic) is used to treat erectile dysfunction (ED, impotence). It increases blood flow to the penis following sexual stimulation by blocking the enzyme responsible for the breakdown of cGMP. This allows men to keep an erection hard enough for sex.
| Parameter | Value | Description | Notes |
|---|---|---|---|
| Absorption | Rapid | Peak plasma levels in 30-120 mins | After oral administration |
| Bioavailability | 40% | Percentage of dose reaching systemic circulation | Subject to food effects |
| Half-life | 4 hours | Time for plasma concentration to reduce by half | --- |
| Metabolism | Liver (CYP3A4 enzymes) | Mainly via CYP3A4 and CYP2C9 | |
| Excretion | Feces and urine | 80% via feces, 13% via urine |
Sildenafil (Viagra, Vybrique brands and generic) only works following sexual stimulation.
| Product | Dosage | Quantity + Bonus | Price | |
|---|---|---|---|---|
| Kamagra | 100mg | 180 + 6 Pills | 436.79€ 415.99€ | |
| Viagra Generic | 200mg | 60 + 4 Pills | 125.19€ 119.23€ | |
| Viagra Generic | 150mg | 90 + 6 Pills | 147.18€ 140.17€ | |
| Viagra Generic | 25mg | 360 + 10 Pills | 213.68€ 203.50€ | |
| Viagra Generic | 25mg | 10 Pills | 25.19€ 23.99€ | |
| Kamagra | 100mg | 120 + 6 Pills | 330.74€ 314.99€ | |
| Kamagra Polo | 100mg | 60 + 4 Pills | 189.39€ 180.37€ | |
| Kamagra Oral Jelly | 100mg | 10 Sachets | 54.55€ 51.95€ | |
| Viagra Generic | 200mg | 10 Pills | 40.96€ 39.01€ | |
| Kamagra Soft Tabs | 100mg | 32 Pills | 120.11€ 114.39€ | |
| Kamagra | 100mg | 32 Pills | 121.24€ 115.47€ | |
| Kamagra Polo | 100mg | 32 Pills | 125.88€ 119.89€ | |
| Kamagra | 100mg | 84 + 6 Pills | 264.44€ 251.85€ |
It works within 30 to 60 minutes, but may be taken up to four hours before sexual activity.
| Drug Class | Interaction Effect | Clinical Significance |
|---|---|---|
| Nitrates | Potentiates hypotension | Absolute contraindication |
| Alpha-blockers | Increased hypotensive effect | Use with caution |
| CYP3A4 inhibitors | Increased sildenafil levels | Dose adjustment needed |
| Protease inhibitors | Elevates sildenafil exposure | Increased side effects |
Sildenafil (Revatio brand) reduces high blood pressure associated with pulmonary arterial hypertension (PAH).
- Sildenafil can cause sudden vision loss (rare side effect).
- Men with a history of retina problems should use caution.
- It may cause a drop in blood pressure, leading to dizziness.
- Patients should report any persistent erection lasting over 4 hours.
- It is crucial to have proper medical evaluation before use.
- Not suitable for individuals with severe liver or kidney conditions.
- The medication is also investigated for breast cancer treatment.
- Proper hydration can help minimize some side effects.
This improves the ability to exercise in people with PAH and delays any worsening of their symptoms. When used to treat PAH, sildenafil is available as tablets (20 mg) for and an IV injection. When used for ED, sildenafil is available as oral tablets of 25 mg, 50 mg, and 100 mg strengths, or an oral film (Vybrique brand) of 25 mg, 50 mg, 75 mg, and 100 mg strengths. If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include: Dyspepsia, flushing, headache, indigestion, muscle or back pain, and visual disturbances are the most common side sildenafil oral solution effects reported. Other side effects include a drop in blood pressure, insomnia, nasal congestion, or a runny nose and nosebleeds. Sudden hearing loss has also been reported. Some people taking sildenafil have had bleeding events; however, it has not been established if this is related to sildenafil use. Rarely, may decrease blood flow to the optic nerve causing sudden vision loss. The risk is greater in people aged older than 50, with diabetes, heart disease, high blood pressure, high cholesterol, who smoke, or with certain pre-existing eye problems.
Adverse effects
Be sure to avoid doing this when the weather is very hot or very cold. If you’re taking this drug for PAH, your doctor may monitor your blood pressure and pulse regularly. When filling your prescription, be sure to call ahead to make sure your pharmacy carries it. Many insurance companies require prior authorization for this drug. This means your doctor may need to get approval from your insurance company before your insurance company will pay for the prescription.
What is Sildenafil Citrate used for?
Sildenafil under the brand name Viagra is prescribed to treat erectile dysfunction by increasing blood flow to the penis during arousal. Sildenafil under the brand name Revatio is often prescribed to help adults with PAH get more exercise by treating their condition. What if I forget to take it? If you are taking Revatio and you forget to take your scheduled dose, take it as soon as possible. However, you should never double your dosage.
Sildenafil Tablets for ED
If you completely miss a dose and it’s time for the next dose, skip the one you missed. Are there any safety measures I should take before using this drug? Like most medications, there are precautions you should take before using this drug. Make sure you talk with your doctor about: any other drugs, medications, herbs, or supplements you take or plan to take any medical conditions or surgeries you have or plan to have if you are pregnant or plan to become pregnant There are other drugs available to treat your condition. Some may be better suited for you than others. Rarely, may cause other side effects or lead to painful erections lasting longer than four hours. See your doctor immediately if this happens. May not be suitable for some people including those with angina, chest pain, other heart conditions, liver or kidney problems, blood or bleeding disorders, stomach ulcers, certain eye conditions, or a physical deformity of the penis (such as Peyronie's disease). Higher dosages of sildenafil are associated with a higher risk of death in children with PAH. For this reason, the FDA does not recommend use in children aged less than 18 years.
What should I know about storage and disposal of this medication?
Viagra is also known as “the little blue pill” because of its blue color, while generic sildenafil tends to be a white color. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or other healthcare professional sildenafil 100g before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. May interact with some medications including certain antibiotics and antifungals, herbal remedies, HIV medicines, nitrates, and drugs used in the treatment of high blood pressure or prostate disorders. Sildenafil should not be taken with other PDE-5 inhibitors. The dosage may need to be reduced in people with kidney or liver disease. More research is needed to establish if sildenafil has a role in sexual dysfunction in women. Sildenafil offers no protection against sexually transmitted diseases.
What to avoid
When you take the drug depends on the condition being treated:For ED: You can take this drug at any time of day.For PAH: Take this drug three times per day about 4–6 hours apart. Take it at the same time every day. For ED: You can take this drug at any time of day. For PAH: Take this drug three times per day about 4–6 hours apart. Store sildenafil tablets at room temperature between 59°F and 86°F (15°C and 30°C).
Some side effects can be serious. If you experience any of the following symptoms, call your doctor immediately:
Don’t store this medication in moist or damp areas, such as bathrooms. A prescription for this medication is refillable. You should not need a new prescription for this medication to be refilled. Your doctor will write the number of refills authorized on your prescription. When flying, never put it into a checked bag.
Interaction médicamenteuse
Keep it in your carry-on bag. Don’t worry about airport X-ray machines. You may need to show airport staff the pharmacy label for your medication. Always carry the original prescription-labeled container with you. Don’t put this medication in your car’s glove compartment or leave it in the car. Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. Sildenafil is used to treat erectile dysfunction (ED) (Viagra, Vybrique brands, generic) and to reduce blood pressure in pulmonary arterial hypertension (PAH) (Revatio brand). It is taken when needed for ED approximately 1 hour before sexual stimulation (maximum dose once daily) and daily for PAH.