New and Emerging Drug Therapies for PE

It's common to feel embarrassed about discussing sexual health concerns. But don't let that keep you from talking to your provider. A conversation with a care provider might help lessen concerns. For example, it might be reassuring to hear that it's typical to experience premature ejaculation from time to time. It may also help to know that the average time from the beginning of intercourse to ejaculation is about five minutes.

See also

Lifelong premature ejaculation occurs all or nearly all the time beginning with the first sexual encounter. Acquired premature ejaculation develops after having previous sexual experiences without problems with ejaculation. Many people feel that they have symptoms of premature ejaculation, but the symptoms don't meet the criteria for a diagnosis. It's typical to experience early ejaculation at times. Talk with your health care provider if you ejaculate sooner than you wish during most sexual encounters. Please, try again in a couple of minutes The exact cause of premature ejaculation isn't known. It was once thought to be only psychological. But health care providers now know that premature ejaculation involves a complex interaction of psychological and biological factors. Psychological factors that might play a role include: Guilty feelings that can cause you to rush through sex Other factors that can play a role include: Being anxious about getting and keeping an erection might form a pattern of rushing to ejaculate.

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The pattern can be difficult to change.

Topical anesthetic agents

U.S. Food and Drug Administration (FDA). Information for consumers on using dietary supplements. Hims & Hers has strict sourcing guidelines to ensure our content is accurate and current. We rely on peer-reviewed studies, academic research institutions, and medical associations.

Masturbation aid device

We strive to use primary sources and refrain from using tertiary references. Doctor of Medicine - Ludwig-Maximilians-University, 2014 Doctor of Medicine - Ludwig-Maximilians-University, 2014 Board Certified Medical Affairs Specialist - Accreditation Council for Medical Affairs, 2024 Board Certified Medical Affairs Specialist - Accreditation Council for Medical Affairs, 2024 Dr. Gussone has contributed widely to consumer health news media, including NBC News TODAY and NBC Nightly News, and has written about his own weight loss journey for CNN. Dr. Gussone has contributed widely to consumer health news media, including NBC News TODAY and NBC Nightly News, and has written about his own weight loss journey for CNN.

Treatment Options For Premature Ejaculation

Dr. Gussone discovered his passion for creating medical content and educating the public about health while working with CNN’s Dr. Sanjay Gupta. He realized that the media could deliver essential health information to millions, surpassing the reach of one-on-one care in a clinical setting. Scuba diving, traveling, cinema, and perfume making Scuba diving, traveling, cinema, and perfume making Erectile dysfunction is a condition in which you have trouble getting or keeping an erection firm enough for satisfying sex. It's common for premature ejaculation and anxiety to occur together.

• Dapoxetine is specifically designed for on-demand use in PE.
• Topical anesthetics require minimal use to avoid excessive numbness.
• SSRIs impact neurotransmitters involved in ejaculation control.
• Tramadol's side effects limit its routine use for PE.
• Non-drug approaches include psychological counseling and exercises.
• Pelvic strengthening exercises aid in delay of ejaculation.
• Partner education enhances understanding and support.
• Managing stress and anxiety can significantly improve PE.
• Some therapies combine medication with sex therapy sessions.
• Medical evaluation is essential before initiating treatment.
• Lifestyle factors like smoking can influence sexual performance.
• Patient adherence to treatment plans improves outcomes.

The anxiety may be about sexual performance or related to other issues. Relationship issues can contribute to premature ejaculation.

How to prevent premature ejaculation

Erectile dysfunction affects as many as 30 million men in the United States. Premature ejaculation (PE) is a sexual dysfunction characterized by a short ejaculatory latency, a perceived lack of control about the timing of ejaculation, and distress and interpersonal difficulty related gel erectile dysfunction to ejaculating too quickly. Low testosterone or testosterone deficiency, also known as hypogonadism, is a condition in which patients develop symptoms such as low sex drive, erectile dysfunction (ED), and fatigue because the body doesn’t produce enough testosterone. Though many men don’t like to talk about it, ejaculation problems are very common. Some of the most common issues include premature, delayed, or retrograde ejaculation.

The pause-squeeze technique

Your pelvic floor is a lot like plumbing in your home: you never really think about it unless something goes wrong. When you think of male sexual dysfunction, concerns like erectile dysfunction (ED) or premature ejaculation (PE) probably come to mind first. But there’s another sex-related issue that’s more common in men than you might expect: difficulty orgasming. Premature ejaculation occurs in men when semen leave the body (ejaculate) sooner than wanted during sex. Premature ejaculation is a common sexual complaint. This may be true if you've had sexual relationships with other partners in which premature ejaculation didn't happen often.

Product Name	Active Ingredient	Application Method	Onset of Action	Duration	Potential Side Effects	Regulation	Effectiveness Rate	Price Range (USD)
EMLA Cream	Lidocaine, Prilocaine	Apply to glans penis	10-15 minutes	30-60 min	Numbness, irritation	OTC	70-80%	10-20
Promescent	Lidocaine-based spray	Sprayed before sex	Immediate	15-30 min	Reduced sensation	OTC	75-85%	20-30
Plexus Neo	Lidocaine patch	Applied to penis	10-20 min	Up to 1 hour	Local irritation	Prescription	60-75%	15-25

A number of biological factors might contribute to premature ejaculation. Swelling and infection of the prostate or urethra Various factors can increase the risk of premature ejaculation.

What Are the Signs and Symptoms of Premature Ejaculation?

As many as 1 out of 3 people say they have it at some time. Premature ejaculation isn't cause for concern if it doesn't happen often. But you might be diagnosed with premature ejaculation if you: Always or nearly always ejaculate within 1 to 3 minutes of penetration Are not able to delay ejaculation during sex all or nearly all the time Feel distressed and frustrated, and tend to avoid sexual intimacy as a result Medications, counseling and techniques that delay ejaculation can help improve sex for you and your partner. The main symptom of premature ejaculation is not being able to delay ejaculation for more than three minutes after penetration. But it might occur in all sexual situations, even during masturbation. You might be at increased risk of premature ejaculation if you have trouble getting or keeping an erection. Fear of losing an erection might cause you to hurry through sex. This may happen whether you're aware of it or not. Emotional or mental strain in any area of life can play a role in premature ejaculation. Stress can limit the ability to relax and focus during sex.

• Dapoxetine is contraindicated with certain medications and health conditions.
• Topical creams should be used sparingly to prevent partner numbness.
• SSRI treatment may cause emotional blunting or decreased libido.
• Tramadol's risk of dependency requires careful medical supervision.
• Mechanical devices can provide temporary ejaculation delay.
• Behavioral training involves specific sex exercises for control.
• Mindfulness and relaxation techniques benefit PE management.
• Proper diagnosis is essential to rule out underlying disorders.
• Incorporate partner feedback to improve treatment results.
• Avoid abrupt discontinuation of prescribed medication.
• Lifestyle modifications can include weight management.
• Ongoing research aims to develop more effective PE treatments.

Premature ejaculation can cause issues in your personal life. A common complication of premature ejaculation is relationship stress.

The bottom line

These numbing agents can be good alternatives to prescription medications for PE. You can find benzocaine as an active ingredient in Hims Clockstopper Climax Delay Wipes, which are designed for quick and easy use five minutes before sex. Benzocaine and lidocaine are topical anesthetics that, when applied to the penis, help you avoid premature ejaculation by reducing sensitivity in the penis. Like premature ejaculation sprays, these numbing creams contain topical anesthetics such as lidocaine to or benzocaine to lower the sensitivity level of your penis and help you avoid ejaculating too soon. Some condoms have benzocaine on the inside to desensitize the penis during sex — and help you stay safe at the same time.

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Techniques like the stop-start strategy and squeeze technique appear to help prevent PE. We’ve covered the squeeze technique and others (and the scientific research on their effectiveness) in our guide to stopping premature ejaculation. PE sometimes has psychological causes, such as sexual performance anxiety. Because of that, some forms of behavioral therapy may help treat it, including cognitive-behavioral therapy (CBT) and sex therapy. Also referred to as Kegel exercises, pelvic floor exercises involve strengthening the pelvic floor muscles to help control ejaculation.

When should I see a doctor about my premature ejaculation symptoms?

Research shows Kegel exercises can often improve ejaculatory control and delay orgasm in men with PE. While it’s certainly far from scientific, some people claim that masturbation before sex helps delay orgasm and ejaculation by keeping you in the post-sex refractory period. Some men with PE can last longer by focusing more on foreplay instead of penetrative sex. Step into your local sex store or gas station — or do a quick search online — and you’ll find countless supplements promising to help you last longer in bed. You can also grab a 64-ounce soda and some lottery tickets. Premature ejaculation can sometimes make it hard for a partner to get pregnant. This may happen if ejaculation doesn't occur in the vagina.

Drug Name	Approval Year	Primary Use	Recommended Dosage	Prescription Needed	Monitor Required	Typical Side Effects
Dapoxetine	2009	Premature ejaculation	30 mg before sex	Yes	Yes	Nausea, dizziness
Paroxetine	Approved for other uses, off-label for PE	20 mg/day	Yes	Yes	Yes	Fatigue, sexual dysfunction
Sertraline	Approved for depression, off-label for PE	50 mg/day	Yes	Yes	Yes	Insomnia, digestive issues

Premature ejaculation occurs when a man reaches orgasm and ejaculates too quickly and without control. In other words, ejaculation occurs before a man wants it to happen.

Ethics declarations

Most of the time, these products contain herbal ingredients like horny goat weed that might help improve sexual performance in a general “yay, vitamins” kind of way. But they’re far from anything close to a treatment. These products also aren’t regulated by the FDA in the same way as prescription medications, meaning they can be marketed using claims that are misleading. They may also contain undisclosed or harmful substances, including prescription drug analogues in unknown quantities, with real side effects. Until PE gets its own medication class, certain antidepressants and ED meds are your best treatment options for premature ejaculation.

No awkward doctor visits. Get premature ejaculation treatment all online.

Whether you’re ready to try pills to last longer in bed or want to give the home remedies more time to work, here’s what to remember: You’re not alone if you’re dealing with PE. Premature ejaculation is a common issue that can affect men of all ages. You’re not alone if you’re dealing with PE. As with erectile dysfunction and other common medical conditions, there’s no shame in using premature ejaculation medication to treat PE and improve your sexual performance, sexual relationship with your partner(s), sexual health, or your own personal sexual pleasure. The solution is to get treated safely.

Authors and Affiliations

Stick to proven prescription treatments, such as sertraline, paroxetine, or sildenafil, or use over-the-counter options like products containing lidocaine or benzocaine. Hims offers access to these prescription premature ejaculation treatments online, following an online consultation with a licensed healthcare provider who can determine if a prescription is appropriate. Explore more options on how to improve your sexual stamina in our blog. Premature ejaculation and endocrine disorders: a literature review. Treatment of premature ejaculation with sertraline hydrochloride.