Drug Interactions with Vardenafil

What other drugs will affect Levitra?
Common side effects of Levitra vs. Viagra
New Drug Levitra Shows Promise in Treatment of Erectile Dysfunction
Trial summary
What are the main differences between Levitra and Cialis?

Verapamil: (Major) Do not use vardenafil orally disintegrating tablets with verapamil due to increased vardenafil exposure; do not exceed a single dose of 5 mg per 24-hour period of vardenafil oral tablets.

What other drugs will affect Levitra?

Trifluoperazine is associated with a possible risk for QT prolongation. Triptorelin: (Moderate) Concomitant use of vardenafil and androgen deprivation therapy (i.e., triptorelin) may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Tucatinib: (Major) Do not use vardenafil orally disintegrating tablets with tucatinib due to increased vardenafil exposure; do not exceed a single dose of 2.5 mg per 24-hour period of vardenafil oral tablets. Vardenafil is primarily metabolized by CYP3A4/5; tucatinib is a strong CYP3A4 inhibitor. Venlafaxine: (Moderate) Concomitant use of vardenafil and venlafaxine may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Vericiguat: (Contraindicated) Use of vericiguat and vardenafil is contraindicated due to the risk of hypotension.

Aspect	Description
Drug Name	Levitra
Generic Name	Vardenafil
Drug Class	Phosphodiesterase type 5 inhibitor
Approved Uses	Erectile dysfunction

PDE5 inhibitors, including vardenafil, may potentiate the hypotensive effects of vericiguat.

Product	Dosage	Quantity + Bonus	Price
Levitra Generic	60mg	180 + 10 Pills	501.43€ 477.55€
Levitra Generic	10mg	30 + 4 Pills	62.39€ 59.42€
Levitra Original	20mg	14 + 2 Pills	102.27€ 97.40€
Levitra Generic	20mg	30 + 4 Pills	70.59€ 67.23€
Levitra Generic	10mg	120 + 10 Pills	178.59€ 170.09€
Levitra Professional	20mg	120 + 4 Pills	348.44€ 331.85€
Levitra Soft Tabs	20mg	270 + 10 Pills	521.78€ 496.93€
Levitra Original	20mg	76 + 4 Pills	344.39€ 327.99€
Levitra Generic	10mg	270 + 10 Pills	338.09€ 321.99€
Levitra Generic	20mg	270 + 10 Pills	376.33€ 358.41€
Levitra Generic	60mg	30 + 2 Pills	109.43€ 104.22€
Levitra Soft Tabs	20mg	120 + 8 Pills	288.52€ 274.78€
Levitra Generic	40mg	120 + 8 Pills	302.37€ 287.97€
Levitra Soft Tabs	20mg	10 Pills	52.27€ 49.78€
Levitra Professional	20mg	180 + 4 Pills	502.31€ 478.39€
Levitra Generic	60mg	360 + 10 Pills	906.69€ 863.51€

Vigabatrin: (Major) Vigabatrin should not be used with phosphodiesterase inhibitors, which is associated with serious

Common side effects of Levitra vs. Viagra

Coadministration may alter plasma concentrations of vardenafil resulting in an increased risk of adverse reactions and/or decreased efficacy. In vitro data predicts inhibition or induction of CYP3A4 by stiripentol potentially resulting in clinically significant interactions. Sunitinib: (Moderate) Concomitant use of vardenafil and sunitinib may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Tacrolimus: (Moderate) Concomitant use of vardenafil and tacrolimus may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Tamoxifen: (Moderate) Concomitant use of tamoxifen and vardenafil may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients.

What is vardenafil used for?

Tamsulosin: (Moderate) Due to the potential for symptomatic hypotension, patients should be stable on tamsulosin therapy before initiating therapy with the lowest dose of vardenafil. Telavancin: (Moderate) Concomitant use of vardenafil and telavancin may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Terazosin: (Moderate) Due to the potential for symptomatic hypotension, patients should be stable on alpha-blocker therapy before initiating therapy with the lowest dose of vardenafil. Tetrabenazine: (Major) Concomitant use of vardenafil and tetrabenazine increases the risk of QT/QTc prolongation and torsade de pointes (TdP). Thioridazine: (Contraindicated) Avoid concomitant use of vardenafil and thioridazine due to an increased risk for torsade de pointes (TdP) and QT/QTc prolongation.

Does Levitra have fewer side effects than Viagra?

Tipranavir: (Major) Do not use vardenafil orally disintegrating tablets with tipranavir boosted with ritonavir due to increased vardenafil exposure; do not exceed a single dose of 2.5 mg per 72-hour period of vardenafil oral tablets. Tolterodine: (Major) Due to the potential for QT prolongation and torsade de pointes (TdP), caution is advised when administering tolterodine with vardenafil. Tolterodine has been associated with dose-dependent prolongation of the QT interval, especially in poor CYP2D6 metabolizers. Therapeutic (10 mg) and supratherapeutic (80 mg) doses of vardenafil also produce an increase in QTc interval (e.g., 4 to 6 msec calculated by individual QT correction). Toremifene: (Major) Concomitant use of vardenafil and toremifene increases the risk of QT/QTc prolongation and torsade de pointes (TdP). ophthalmic effects (e.g., retinopathy or glaucoma) unless the benefit of treatment clearly outweighs the risks.

Step	Description
PDE5 inhibition	Blocks enzyme PDE5, increasing cGMP levels
Increased cGMP	Causes smooth muscle relaxation in corpora cavernosa
Erection initiation	Blood flow into the penis increases, facilitating an erection

Voclosporin: (Moderate) Concomitant use of vardenafil and voclosporin may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients.

Side Effect	Frequency	Severity	Notes
Headache	Common	Mild to moderate	Usually transient
Flushing	Common	Mild	Warmth sensation
Nasal congestion	Common	Mild	Nasal stuffiness
Dizziness	Less common	Mild	Upon standing quickly
Indigestion	Common	Mild	Gastrointestinal upset

The degree of QT prolongation associated with voclosporin is not clinically significant when administered within

Levitra has been shown to enhance erectile function in clinical studies.
It is not classified as a controlled substance but still requires caution.
Side effects usually diminish after the body adjusts to the medication.
Patients should inform their doctor of all health issues before starting Levitra.
In some cases, Levitra may be used temporarily or as needed.
Regular blood pressure monitoring is recommended when using Levitra.
Levitra should be stored safely away from children and pets.
Discuss all medication options with a healthcare provider to find the best treatment.

the recommended dosage range; QT prolongation has been described at 3 times the maximum recommended dose.

New Drug Levitra Shows Promise in Treatment of Erectile Dysfunction

Vardenafil can produce QT prolongation at both therapeutic and supratherapeutic doses. Ribociclib; Letrozole: (Major) Concurrent use of vardenafil orally disintegrating tablets with ribociclib should be avoided due to increased vardenafil exposure. Rilpivirine: (Moderate) Concomitant use of vardenafil and rilpivirine may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Riociguat: (Contraindicated) Use of riociguat and vardenafil is contraindicated due to the risk of hypotension. Discontinue riociguat at least 24 hours prior to vardenafil administration.

Dosage for ED

Monitor for signs and symptoms of hypotension during transition of therapy. PDE5 inhibitors, including vardenafil, may potentiate the hypotensive effects of riociguat. Risperidone: (Moderate) Concomitant use of vardenafil and risperidone may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Ritlecitinib: (Major) Do not use vardenafil orally disintegrating tablets with ritlecitinib due to increased vardenafil exposure; do not exceed a single dose of 5 mg per 24-hour period of vardenafil oral tablets. Vardenafil is primarily metabolized by CYP3A; ritlecitinib is a moderate CYP3A inhibitor.

Who Should Not Take Viagra™

Ritonavir: (Major) Do not use vardenafil orally disintegrating tablets with ritonavir due to increased vardenafil exposure; do not exceed a single dose of 2.5 mg per 72-hour period of vardenafil oral tablets. Romidepsin: (Moderate) Concomitant use of vardenafil and romidepsin may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Sapropterin: (Moderate) Sapropterin acts as a cofactor in the synthesis of nitric oxide and may cause vasorelaxation. Caution should be exercised when administering sapropterin in combination with drugs that affect nitric oxide-mediated vasorelaxation such as phosphodiesterase inhibitors. When given together these agents may produce an additive reduction in blood pressure. Vonoprazan; Amoxicillin; Clarithromycin: (Major) Do not use vardenafil orally disintegrating tablets with clarithromycin due to increased vardenafil

Trial summary

Trandolapril; Verapamil: (Major) Do not use vardenafil orally disintegrating tablets with verapamil due to increased vardenafil exposure; do not exceed a single dose of 5 mg per 24-hour period of vardenafil oral tablets. Vardenafil is primarily metabolized by CYP3A and verapamil is a moderate CYP3A inhibitor. Trazodone: (Major) Concomitant use of vardenafil and liquid levitra trazodone increases the risk of QT/QTc prolongation and torsade de pointes (TdP). Triclabendazole: (Moderate) Concomitant use of triclabendazole and vardenafil may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Trifluoperazine: (Minor) Use vardenafil with caution in combination with trifluoperazine as concurrent use may increase the risk of QT prolongation. exposure; do not exceed a single dose of 2.5 mg per 24-hour period of vardenafil oral tablets.

Levitra may interact with other medications like alpha-blockers for prostate issues.
Use caution when combining Levitra with other vasodilators.
Patients should avoid excessive alcohol when taking Levitra to prevent adverse effects.
It is important to stay hydrated and avoid dehydration during treatment.
Levitra's effectiveness can be reduced by certain health conditions, like obesity.
Men with certain eye conditions should have medical clearance before use.
Levitra may cause dizziness; patients should stand slowly from sitting or lying.
Overdose symptoms include prolonged erections and cardiovascular symptoms; seek immediate help.

Voriconazole: (Major) Do not use vardenafil orally disintegrating tablets with voriconazole due to increased vardenafil exposure; do not exceed a single dose of 2.5 mg per 24-hour period of vardenafil oral tablets.

Levitra is available by prescription only and should be used under medical supervision.
It is important to follow the prescribed dosage for safety and effectiveness.
Levitra does not cause an instant erection; sexual stimulation is required.
Alcohol consumption can reduce Levitra's effectiveness and increase side effects.
Patients with heart problems should consult their doctor before taking Levitra.
Levitra was approved by the FDA for the treatment of erectile dysfunction in 2003.
In rare cases, Levitra may cause side effects like sudden vision loss.
Taking Levitra with certain medications can cause dangerous drops in blood pressure.

Vardenafil is primarily metabolized by CYP3A4/5; voriconazole is a strong CYP3A4 inhibitor.

What are the main differences between Levitra and Cialis?

The combination of sapropterin and a phosphodiesterase (PDE5) inhibitor did not significantly reduce blood pressure when administered concomitantly in animal studies. The additive effect of these agents has not been studied in humans. Saquinavir: (Contraindicated) Coadministration of saquinavir boosted with ritonavir is contraindicated with other drugs that may prolong the QT interval and which are primary CYP3A4 substrates, such as vardenafil. Saquinavir boosted with ritonavir is a strong CYP3A4 inhibitor that increases the QT interval in a dose-dependent fashion. Selpercatinib: (Major) Concomitant use of vardenafil and selpercatinib increases the risk of QT/QTc prolongation and torsade de pointes (TdP).

How will my doctor determine whether Viagra or Levitra is better for me?

Sertraline: (Moderate) Concomitant use of vardenafil and sertraline may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. The degree of QT prolongation associated with sertraline is not clinically significant when administered within the recommended dosage range; QT prolongation has been described at 2 times the maximum recommended dose. Silodosin: (Moderate) Due to the potential for symptomatic hypotension, patients should be stable on silodosin therapy before initiating therapy with the lowest dose of vardenafil. Conversely, patients already receiving an optimized dose of vardenafil should be started on the lowest dose of silodosin; increases in the alpha-blocker dose should be done in a stepwise fashion. Other variables, such as intravascular volume depletion, concurrent antihypertensive therapy, or evidence of hemodynamic instability with alpha-blocker monotherapy, may affect the safety of concomitant use of vardenafil and silodosin.

Who should not take Cialis:

Siponimod: (Major) Concomitant use of vardenafil and siponimod increases levitra shipping the risk of QT/QTc prolongation and torsade de pointes (TdP). Sodium Stibogluconate: (Moderate) Concomitant use of sodium stibogluconate and vardenafil may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Solifenacin: (Moderate) Concomitant use of vardenafil and solifenacin may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients. Sotalol: (Major) Concomitant use of vardenafil and sotalol increases the risk of QT/QTc prolongation and torsade de pointes (TdP). Stiripentol: (Moderate) Consider a dose adjustment of vardenafil when coadministered with stiripentol. In addition, voriconazole has been associated with QT prolongation and rare cases of torsade de pointes.

Levitra is not suitable for men with severe liver or kidney impairment.
Do not take Levitra with other medications containing nitrates for chest pain.
Older adults should use Levitra with caution due to potential side effects.
Levitra is sometimes used in clinical trials for other conditions.
Keep Levitra out of reach of children due to potential toxicity.
Store Levitra in a cool, dry place and away from direct sunlight.
Patients should inform their healthcare provider about all current medications.
Levitra can cause priapism, a prolonged erection requiring medical attention.

Vorinostat: (Moderate) Concomitant use of vardenafil and vorinostat may increase the risk of QT/QTc prolongation and torsade de pointes (TdP) in some patients.